商品介绍
| Description | |
|---|---|
| CatalogueNumber | 15-203 |
| TradeName |
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| Description | Alzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-Pack |
| BackgroundInformation | PathwayInvestigatorAntibodyMiniPack: EachPathwayExplorerAntibodyMinipackcontainsthreerelatedantibodiesaspartofasignalingcascadeoracombinationoftotalandphosphorylatedformsofkeysignalingtargets.Eachofthethreeantibodiesare30%theoriginalpacksize.FullsizeversionsofeachofthePathwayExplorerantibodiesareavailableforsaleindividuallyunderthesamecatalognumberwiththeremovalof“SP”offofeachone(e.g.05-591SPcanbeorderedas05-591). AlzheimerPrecursorProteinA4,clone22C11: DepositsofamyloidproteininsenileplaquesnearnerveprocessesarefoundinthebrainsofagedhumandandcasesofAlzheimer"sDisease.Theprinciplecomponentofthisextracellularamyloidisbeta/A4,a4kDapeptidederivedfromalargeramyloidprecursorprotein(APP),whichiswidelyexpressedinthebrainandbody.Thecreation,transportandfunctionoftheseproteinsarecurrentlyunderinvestigation. 14-3-3-eC-Terminus: Mammalsexpresssevendistinct14-3-3isoforms(gamma,epsilon,beta,zeta,sigma,theta,tau)thatformmultiplehomo-andhetero-dimmers,thusrendering14-3-3asakeymultifunctionalregulatorymolecule.14-3-3isomershavebeenimplicatedinseveralneurologicaldisorders:forexampleisoformsgamma,epsilonandbetaareexpressedinthecerebrospinalfluidofCreutzfeldt-Jakobpatients,butnotpatientssufferingfromotherneurologicalconditionssuchasAlzheimer"s. The14-3-3epsilon,C-terminalantibodyisoneofapanelofantibodiesthatweregeneratedagainst14-3-3isoformsandhavedemonstratedtheirpotentialforuseasanELISA-baseddiagnostictool.TheseantibodieswillallowtheresearchtoinvestigatetheroleofthisproteininkeycellularprocessesandneurologicaldisorderssuchasCreutzfeldt-Jakob,Alzheimer"sandParkinson"sDisease. *Seefullsizeversionsforcorrespondingreferences. |
| ProductInformation | |
|---|---|
| Components |
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| Presentation | 3individualtubescontainingeitherAnti-AlzheimerPrecursorProteinA4,clone22C11;Anti-14-3-3epsilon,C-terminal;orAnti-AGE(AdvancedGlycationEnd-products) |
| Properties | Eachvialis30%thesizeoftheparentcatalognumber |
| StorageandShippingInformation |
|---|
| Applications | |
|---|---|
| Application | Alzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-Pack. |
| BIOLOGicalInformation | |
|---|---|
| CrossReactivity | Varies.SeeindividualDataSheets |
| EntrezGeneNumber | |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P62258#Adapterproteinimplicatedintheregulationofalargespectrumofbothgeneralandspecializedsignalingpathway.Bindstoalargenumberofpartners,usuallybyrecognitionofaphosphoserineorphosphothreoninemotif.Bindinggenerallyresultsinthemodulationoftheactivityofthebindingpartner. SIZE:255aminoacids;29174Da SUBUNIT:Homodimer.InteractswithNDEL1(Bysimilarity).InteractswithHCVcoreprotein. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Melanosome.Note=IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV. SIMILARITY:SwissProt:P62258##Belongstothe14-3-3family. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
Millipore常用产品报价单
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |
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