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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Millipore/553510 | RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem/553510/
产品编号:553510
市  场 价:¥2240.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$112.00
品      牌: Millipore
公      司:Millipore
公司分类:
Millipore/553510 | RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem/553510/
商品介绍
Description
OverviewAcell-permeablesulfonamido-benzamide-basedallostericregulatorthatstimulatesDNAbindingandrecombinaseactivitiesofhRAD51bylockinghRAD51inanactiveconformationwithoutaffectingitsactivesiteATPhydrolysis.AlthoughRS-1enhanceshRAD51filamentformationonssDNAwithorwithoutthecofactorNTP,activefilamentsandrecombinaseactivityareonlyinducedinthepresenceofATPorAMP-PNP,butnotwithADPornocofactors.ShowntopromoteresistanceofprimaryhumanneonataldermalfibroblaststoCisplatin-(Cat.No.232120)induceddeathinadose-dependentmanner.RS-1isinactivetowardrelatedDNAstrandexchangeproteinsscRAD5andscDMC1ofyeastoriginorE.coliRedA.ThisHDR(homology-directedrepair)enhancer,isshowntosignificantlyincreasebothCas9&TALEN-mediatedknock-inefficiencies.
CatalogueNumber553510
BrandFamilyCalbiochem®
Synonyms3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide,RS-1
ProductInformation
CASnumber312756-74-4
FormLightbeigesolid
HillFormulaC₂₀H₁₆Br₂N₂O₃S
ChemicalformulaC₂₀H₁₆Br₂N₂O₃S
StructureformulaImage
StorageandShippingInformation
ShipCodeAmbientTemperatureOnly
ToxicityStandardHandling
Storage+2°Cto+8°C
ProtectfromLightProtectfromlight
DonotfreezeOktofreeze
SpecialInstructionsFollowingreconstitution,aliquotandfreeze(-20°C).Stocksolutionsarestableforup3monthsat-20°C.
Applications
BIOLOGicalInformation
Purity≥95%byHPLC
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
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