Description | |
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Overview | Acell-permeablesulfonamido-benzamide-basedallostericregulatorthatstimulatesDNAbindingandrecombinaseactivitiesofhRAD51bylockinghRAD51inanactiveconformationwithoutaffectingitsactivesiteATPhydrolysis.AlthoughRS-1enhanceshRAD51filamentformationonssDNAwithorwithoutthecofactorNTP,activefilamentsandrecombinaseactivityareonlyinducedinthepresenceofATPorAMP-PNP,butnotwithADPornocofactors.ShowntopromoteresistanceofprimaryhumanneonataldermalfibroblaststoCisplatin-(Cat.No.232120)induceddeathinadose-dependentmanner.RS-1isinactivetowardrelatedDNAstrandexchangeproteinsscRAD5andscDMC1ofyeastoriginorE.coliRedA.ThisHDR(homology-directedrepair)enhancer,isshowntosignificantlyincreasebothCas9&TALEN-mediatedknock-inefficiencies. |
CatalogueNumber | 553510 |
BrandFamily | Calbiochem® |
Synonyms | 3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide,RS-1 |
ProductInformation | |
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CASnumber | 312756-74-4 |
Form | Lightbeigesolid |
HillFormula | C₂₀H₁₆Br₂N₂O₃S |
Chemicalformula | C₂₀H₁₆Br₂N₂O₃S |
StructureformulaImage |
StorageandShippingInformation | |
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ShipCode | AmbientTemperatureOnly |
Toxicity | StandardHandling |
Storage | +2°Cto+8°C |
ProtectfromLight | Protectfromlight |
Donotfreeze | Oktofreeze |
SpecialInstructions | Followingreconstitution,aliquotandfreeze(-20°C).Stocksolutionsarestableforup3monthsat-20°C. |
Applications |
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BIOLOGicalInformation | |
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Purity | ≥95%byHPLC |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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Millipore常用产品报价单
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |