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主营：分子类，蛋白类，抗体类，生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Millipore/14-696 | MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg/14-696/100 µg
产品编号：14-696
市  场 价：¥0.00
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品      牌： Millipore
公      司：Millipore
公司分类：
Millipore/14-696 | MAP Kinase 2/Erk 2 (K52R), inactive, 100 µg/14-696/100 µg
商品介绍
Description
CatalogueNumber14-696
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionMAPKinase2/Erk2(K52R),inactive,100µg
OverviewN-terminal6His-taggedrecombinantfull-lengthmouseMAPKinase2/Erk2containingaK52Rmutation
ProductInformation
StorageandShippingInformation
StorageConditions1yearat-20°Cfromdateofshipment
Applications
ApplicationInactive,N-terminal6His-taggedrecombinantfull-lengthmouseMAPKinase2/Erk2containingaK52Rmutation,foruseinKinaseAssays.
KeyApplications
  • KinaseAssay
BIOLOGicalInformation
SourceexpressedinE.coli
SpecificActivityForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme.
EntrezGeneNumber
EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
GeneSymbol
  • MAPK1
  • p40
  • PRKM2
  • MAPK2
  • PRKM1
  • p42-MAPK
  • p38
  • ERK
  • ERK-2
  • ERT1
  • P54MAPK
  • P41MAPK
  • ERK2
ProteinTargetMAPK2
PurificationMethodNi2+/NTA-agarose
TargetSub-FamilyCMGC
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P63085#Serine/threoninekinasewhichactsasanessentialcomponentoftheMAPkinasesignaltransductionpathway.MAPK1/ERK2andMAPK3/ERK1arethe2MAPKswhichplayanimportantroleintheMAPK/ERKcascade.TheyparticipatealsoinasignalingcascadeinitiatedbyactivatedKITandKITLG/SCF.Dependingonthecellularcontext,theMAPK/ERKcascademediatesdiversebiologicalfunctionssuchascellgrowth,adhesion,survivalanddifferentiationthroughtheregulationoftranscription,translation,cytoskeletalrearrangements.ThetheMAPK/ERKcascadeplaysalsoaroleininitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactors.About160substrateshavealreadybeendiscoveredforERKs.Manyofthesesubstratesarelocalizedinthenucleus,andseemtoparticipateintheregulationoftranscriptionuponstimulation.However,othersubstratesarefoundinthecytosolaswellasinothercellularorganelles,andthoseareresponsIBLeforprocessessuchastranslation,mitosisandapoptosis.Moreover,theMAPK/ERKcascadeisalsoinvolvedintheregulationoftheendosomaldynamics,includinglysosomeprocessingandendosomecyclingthroughtheperinuclearrecyclingcompartment(PNRC);aswellasinthefragmentationoftheGolgiapparatusduringmitosis.
COFACTOR:Magnesium(Bysimilarity).
DOMAIN:TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
MolecularWeight45kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
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