Description | |
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CatalogueNumber | CBL1512F |
Replaces | MAB1404F |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-IntegrinαM[CD11b]Antibody,cloneOX-42,FITCconjugated |
AlternateNames |
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ProductInformation | |
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Format | FITC |
Presentation | Theconjugateissuppliedasa100test/1mLvialinphosphatebufferedsalinecontaining10mMsodiumazideand1mg/mlbovineserumalbumin.Forflowcytometrywerecommendusing10μLofconjugatepertest. |
StorageandShippingInformation | |
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StorageConditions | Storeat+4°Cprotectedfromlight.DONOTFREEZE.Forlongtermuseandstoragealiquotconjugateintosmallvolumesandstoreat+4°C. |
BIOLOGicalInformation | |
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Immunogen | Ratperitonealmacrophages |
Clone | OX-42 |
Host | Mouse |
Specificity | Thisantibodyrecognizesmostmacrophages(includingresidentperitonealandactivatedmacrophages),kupffercells,butonlyabout35%ofalveolarmacrophages.Theantibodyalsolabelsdendriticcellsextensively,granulocytesandcellswiththemorphologyofmicrogliainbrain.Theantibodyprecipitatesthreepolypeptidesof150,103and95KDa.TheantibodyinhibitscomplementmediatedrosettesandisprobablytheratequivalentofthehumanreceptorforIC3bcalledCR3. FUSIONPARTNER:NSOmyelomacellline. |
Isotype | IgG2a |
SpeciesReactivity |
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AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThisgeneencodestheintegrinalphaMchain.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.ThisI-domaincontainingalphaintegrincombineswiththebeta2chain(ITGB2)toformaleukocyte-specificintegrinreferredtoasmacrophagereceptor1("Mac-1"),orinactivated-C3b(iC3b)receptor3("CR3").ThealphaMbeta2integrinisimportantintheadherenceofneutrophilsandmonocytestostimulatedendothelium,andalsointhephagocytosisofcomplementcoatedparticles.SomeintegrinalphaMproteinscontainaninsertedaminoacid(Q,betweenAApositions499and500)resultingfroma3bpshiftinaspliceacceptorthatinsertsthecodonCAG;receptorswithorwithouttheextraaminoacidarefunctionallyindistinguishable |
GeneSymbol |
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UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P11215#Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain. SIZE:1152aminoacids;127179Da SUBUNIT:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes. DOMAIN:SwissProt:P11215TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage. SIMILARITY:Belongstotheintegrinalphachainfamily.&Contains7FG-GAPrepeats.&Contains1VWFAdomain. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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Millipore常用产品报价单
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |