商品介绍
| Description | |
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| CatalogueNumber | 17-320 |
| BrandFamily | Upstate |
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| Description | HistoneDeacetylaseAssayKit(HDAC) |
| Overview | ThiskitcontainsnonrADIoactivecomponentsforradiolabelingandpurifyinghistoneH4peptidewith[3H]-acetylCoA.TheradiolabeledpeptideisasuitablesubstrateforassayofHDACactivity.HeLanuclearextract,whichisrichinhistonedeacetylaseactivity,isincludedasapositivecontrol.TheHDACinhibitorsodiumbutyrateisprovidedtodemonstratespecificityofthedeacetylaseactivity. |
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| BIOLOGicalInformation | |
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| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.TheproteinencodedbythisgenebelongstotheclassIIhistonedeacetylase/acuc/aphafamily.Itpossesseshistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.ItcoimmunoprecipitatesonlywithHDAC3familymemberandmightformmulticomplexproteins.Italsointeractswithmyocyteenhancerfactor-2(MEF2)proteins,resultinginrepressionofMEF2-dependentgenes.Thisgeneisthoughttobeassociatedwithcoloncancer.Twotranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene. |
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| UniProtSummary | FUNCTION:SwissProt:Q9UQL6#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactors. SIZE:1122aminoacids;121992Da SUBUNIT:InteractswithBCOR,HDAC7,HDAC9,CTBP1,MEF2C,NCOR2,NRIP1,PHB2anda14-3-3chaperoneprotein.InteractswithJARID1B. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Shuttlesbetweenthenucleusandthecytoplasm.Inmusclecells,itshuttlesintothecytoplasmduringmyocytedifferentiation.Theexporttocytoplasmdependsontheinteractionwitha14-3-3chaperoneproteinandisduetoitsphosphorylationatSer-259andSer-498byCaMK.TISSUESPECIFICITY:Ubiquitous.DOMAIN:SwissProt:Q9UQL6Thenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasm(Bysimilarity). PTM:PhosphorylatedbyCaMKatSer-259andSer-498.Thephosphorylationisrequiredfortheexporttothecytoplasm.&Ubiquitinated.Polyubiquitinationhoweverdoesnotleadtoitsdegradation. SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily. |
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| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |
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