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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Millipore/F1903 | Fibronectin 40 kDa α Chymotryptic Fragment (Heparin-binding region), Human purified/F1903/500 µg
产品编号:F1903
市  场 价:¥6340.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$317.00
品      牌: Millipore
公      司:Millipore
公司分类:
Millipore/F1903 | Fibronectin 40 kDa α Chymotryptic Fragment (Heparin-binding region), Human purified/F1903/500 µg
商品介绍
Description
CatalogueNumberF1903
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionFibronectin40kDaαChymotrypticFragment(Heparin-bindingregion),Humanpurified
OverviewHeparin-binding40kDafragmentofhumanplasmafibronectinpurifiedfromchymotrypticdigestofhumanplasmafibronectin.ThispreparationcontainstheCS-1heparin-bindingregionoffibronectin.Heparin-bindingfragmentpromotesCytoskeletonorganizationinintegrinsignaling.Thispreparationshowsonemajorbandat40kDainSDS-PAGEwithnohighermolecularweightspeciespresent.Smallerproteolyticfragmentsmaybepresent.

HumansourcedrawmaterialusedintheproductionofthisproducttestednegativeforhepatitisBvirus,hepatitisCvirus(HCV),humanimmunodeficiencyvirustype-1(HIV-1)andtype-2(HIV-2),humanT-celllymphotropicvirus(HTLV-1andHTLV-2)andTreponemapallidum.Handleasifpotentiallyinfectious.
ProductInformation
PresentationPurifiedbygelatin-Sepharose™andheparin-Sepharose™columnchromatography.Lyophilizedfromsodiumcitratebufferedsaline,20mM,NaCl150mM,pH7.4.Reconstitutewithdistilledwater.
StorageandShippingInformation
StorageConditionsMaintainlyophilizedmaterialat-20°Cforuptooneyearfromdateofreceipt.Afterreconstitution,maintainat-20°Cforuptosixmonthsinundilutedaliquots.Avoidrepeatedfreeze/thawcycles.
Applications
KeyApplications
  • CellCulture
ApplicationNotesELISA

Affinitychromatography

PossIBLyformolecularmappingoffibronectinfunction

Cellattachmentandintegrinsignalingassays

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
Concentration1mg/mL
SourceHuman
EntrezGeneNumber
EntrezGeneSummaryThisgeneencodesfibronectin,aglycoproteinpresentinasolubledimericforminplasma,andinadimericormultimericformatthecellsurfaceandinextracellularmatrix.Fibronectinisinvolvedincelladhesionandmigrationprocessesincludingembryogenesis,woundhealing,bloodcoagulation,hostdefense,andmetastasis.Thegenehasthreeregionssubjecttoalternativesplicing,withthepotentialtoproduce20differenttranscriptvariants.However,thefull-lengthnatureofsomevariantshasnotbeendetermined.
GeneSymbol
  • FN1
  • DKFZp686O13149
  • DKFZp686H0342
  • DKFZp686I1370
  • MSF
  • FN
  • CIG
  • DKFZp686F10164
  • LETS
  • FINC
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P02751#Fibronectinsbindcellsurfacesandvariouscompoundsincludingcollagen,fibrin,heparin,DNA,andactin.Fibronectinsareinvolvedincelladhesion,cellmotility,opsonization,woundhealing,andmaintenanceofcellshape.InteractionwithTNRmediatesinhibitionofcelladhesionandneuriteoutgrowth(Bysimilarity).
SIZE:2386aminoacids;262607Da
SUBUNIT:Mostlyheterodimersormultimersofalternativelysplicedvariants,connectedby2disulfidebondsnearthecarboxylends;toalesserextenthomodimers.InteractswithFBLN1,AMBP,TNR,LGALS3BPandCOL13A1.
SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix.
TISSUESPECIFICITY:PlasmaFN(solubledimericform)issecretedbyhepatocytes.CellularFN(dimericorcross-linkedmultimericforms),madebyfibroblasts,epithelialandothercelltypes,isdepositedasfibrilsintheextracellularmatrix.Ugl-Y1,Ugl-Y2andUgl-Y3arefoundinurine.DEVELOPMENTALSTAGE:Ugl-Y1,Ugl-Y2andUgl-Y3arepresentintheurinefrom0to17yearsofage.
PTM:Sulfated.
SIMILARITY:SwissProt:P02751##Contains12fibronectintype-Idomains.&Contains2fibronectintype-IIdomains.&Contains16fibronectintype-IIIdomains.
StemCellType
  • HumanEmbryonicStemCells
  • MesenchymalStemCells
  • NeuralStemCells
  • HematopoieticStemCells
  • EpithelialCells
  • PancreaticStemCells
  • InducedPluripotentStemCells
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
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