商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB9208 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-DARPP-32Antibody,phosphoThr75 |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Presentation | Affinitypurifiedimmunoglobulin.Liquidin10mMHEPES,pH7.5,150mMNaCl,100μgpermLBSAwith50%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cto-80°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidefromhuman/mouseDARPP-32,phosphoThr75. |
| Epitope | phosphoThr75 |
| Host | Rabbit |
| Specificity | DARPP-32,phosphoThr75. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Midbraindopaminergicneuronsplayacriticalroleinmultiplebrainfunctions,andabnormalsignalingthroughdopaminergicpathwayshasbeenimplicatedinseveralmajorneurologicandpsychiatricdisorders.Onewell-studiedtargetfortheactionsofdopamineisDARPP32.Inthedenselydopamine-andglutamate-innervatedratcaudate-putamen,DARPP32isexpressedinmedium-sizedspinyneurons(OuimetandGreengard,1990[PubMed2191086])thatalsoexpressdopamineD1receptors(WalaasandGreengard,1984[PubMed6319627]).ThefunctionofDARPP32seemstoberegulatedbyreceptorstimulation.Bothdopaminergicandglutamatergic(NMDA)receptorstimulationregulatetheextentofDARPP32phosphorylation,butinoppositedirections(Halpainetal.,1990[PubMed2153935]).DopamineD1receptorstimulationenhancescAMPformation,resultinginthephosphorylationofDARPP32(WalaasandGreengard,1984[PubMed6319627]);phosphorylatedDARPP32isapotentproteinphosphatase-1(seeMIM176875)inhibitor(Hemmingsetal.,1984[PubMed6087160]).NMDAreceptorstimulationelevatesintracellularcalcium,whichleadstoactivationofcalcineurinanddephosphorylationofphospho-DARPP32,therebyreducingthephosphatase-1inhibitoryactivityofDARPP32(Halpainetal.,1990[PubMed2153935]).[suppliedbyOMIM] |
| GeneSymbol |
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| Modifications |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9UD71#Inhibitorofprotein-phosphatase1. SIZE:204aminoacids;22963Da SUBCELLULARLOCATION:Cytoplasm. PTM:Dopamine-andcyclicAMP-regulatedneuronalphosphoprotein.&PhosphorylationofThr-34isrequiredforactivity(Bysimilarity). SIMILARITY:SwissProt:Q9UD71##Belongstotheproteinphosphataseinhibitor1family. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
Millipore常用产品报价单
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |
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