Description | |
---|---|
Overview | Acell-permeablebis-indolo(indirubin)compoundthatactsasahighlypotent,selective,reversIBLe,andATP-competitiveinhibitorofGSK-3α/β(IC50=5nM).ItsspecificityhasbeentestedagainstvariousCdk"s(IC50=83,300,320,and10,000nMforCdk5/p25,Cdk2/A,Cdk1/B,andCdk4/D1,respectively)aswellasmanyothercommonlystudiedkinases(IC50≥10µM),includingMAPkinases,PKA,PKCisoforms,PKG,CK,andIRTK.InhibitionofGSKbyBIOhasbeenshowntoresultintheactivationofWnt-signalingpathwayandsustainedpluripotencyinhumanandmurineESCs(embryonicstemcells).Reportedtomaintainself-renewalinhumanandmouseembryonicstemcells.Alsoinducesthedifferentiationofneonatalcardiomyocytes.A10mM(500µg/140µl)solutionofGSK-3InhibitorIX(Cat.No.361552)inDMSOisalsoavailable. |
CatalogueNumber | 361550 |
BrandFamily | Calbiochem® |
Synonyms | BIO,(2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime |
ProductInformation | |
---|---|
CASnumber | 667463-62-9 |
ATPCompetitive | Y |
Form | Purplesolid |
HillFormula | C₁₆H₁₀BrN₃O₂ |
Chemicalformula | C₁₆H₁₀BrN₃O₂ |
Reversible | Y |
StructureformulaImage |
StorageandShippingInformation | |
---|---|
ShipCode | ShippedwithBlueIceorwithDryIce |
Toxicity | Carcinogenic/Teratogenic |
Storage | +2°Cto+8°C |
ProtectfromLight | Protectfromlight |
Donotfreeze | Oktofreeze |
SpecialInstructions | Followingreconstitution,aliquotandfreeze(-20°C).Stocksolutionsarestableforupto3monthsat-20°C. |
Applications |
---|
BIOLOGicalInformation | |
---|---|
PrimaryTarget | GSK-3α/β |
PrimaryTargetIC<sub>50</sub> | 5nMagainstGSK-3α/β |
Purity | ≥97%byHPLC |
PhysicochemicalInformation | |
---|---|
Cellpermeable | Y |
Dimensions |
---|
MaterialsInformation |
---|
MaterialsInformation |
---|
Millipore常用产品报价单
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |