Description | |
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Overview | AnacetoximeanalogofBIO,GSK-3InhibitorIX(Cat.No.361550)thatexhibitsgreaterselectivityforGSK-3α/β(IC50=10nM)overCdk5/p25,Cdk2/AandCdk1/B(IC50=2.4µM,4.3µMand63µM,respectively).WeaklyaffectstheactivitiesofCdk4/D1andmanyotherkinases(IC50≥10µM).AlsoactsasanarylhydrocarbonreceptoragoNISTinbothyeast(EC50≥0.1µM)andmammalian(EC50=0.16µM)reportersystems. |
CatalogueNumber | 361551 |
BrandFamily | Calbiochem® |
Synonyms | (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime,BIO-Acetoxime |
ProductInformation | |
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CASnumber | 740841-15-0 |
ATPCompetitive | N |
Form | Darkpurplesolid |
HillFormula | C₁₈H₁₂BrN₃O₃ |
Chemicalformula | C₁₈H₁₂BrN₃O₃ |
ReversIBLe | N |
StructureformulaImage |
StorageandShippingInformation | |
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ShipCode | AmbientTemperatureOnly |
Toxicity | Carcinogenic/Teratogenic |
Storage | +2°Cto+8°C |
ProtectfromLight | Protectfromlight |
Donotfreeze | Oktofreeze |
SpecialInstructions | Followingreconstitution,aliquotandfreeze(-20°C).Stocksolutionsarestableforupto1monthat-20°C. |
Applications |
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BIOLOGicalInformation | |
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PrimaryTarget | GSK-3α/β |
PrimaryTargetIC<sub>50</sub> | 10nMagainstGSK-3α/β |
Purity | ≥95%byHPLC |
PhysicochemicalInformation | |
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Cellpermeable | N |
Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |