Description | |
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Overview | Theracemicmixtureofacell-permeablepyridocarbazolo-cyclopentADIenylRutheniumcomplexthatactsasareversIBLe,ATP-competitive,andhighlypotentinhibitorofGSK-3(IC50=0.4and0.6nMforGSK-3αandGSK-3β,respectively)with∼5-foldselectivityoverPIM-1kinase(IC50=3nM).Studiesusingisolatedenantiomershaveshownthatthe(R)-enantiomerisGSK-3-selective(IC50=0.35,0.55,and35nMforGSK-3αGSK-3β,andPim-1,respectively)andinterfereswithnormalzebrafishembryodevelopment(1µM),whilethe(S)-enantiomerisPim-1-selective(IC50=80,90,and3nMforGSK-3αGSK-3β,andPim-1,respectively)andexhibitsnoeffectinembryodevelopmentatthesamedosage. |
CatalogueNumber | 361558 |
BrandFamily | Calbiochem® |
ProductInformation | |
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ATPCompetitive | Y |
Declaration | Soldforresearchpurposesonly,pursuanttoanagreementwithUniversityofPennsylvania.SoldunderlicenseofU.S.Patent7,488,817. |
Form | Purplesolid |
HillFormula | C₂₅H₁₄BrN₃O₆Ru |
Chemicalformula | C₂₅H₁₄BrN₃O₆Ru |
Reversible | Y |
StructureformulaImage |
StorageandShippingInformation | |
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ShipCode | BlueIceOnly |
Toxicity | StandardHandling |
Storage | -20°C |
ProtectfromLight | Protectfromlight |
Donotfreeze | Oktofreeze |
SpecialInstructions | Followingreconstitution,aliquotandfreeze(-20°C).Stocksolutionsarestableforupto6monthsat-20°C. |
Applications | |
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Application | GSK-3InhibitorXV,isacell-permeable,reversible,ATP-competitive,andhighlypotentinhibitorofGSK-3(IC50=0.4and0.6nMforGSK-3αandGSK-3β,respectively). |
BIOLOGicalInformation | |
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PrimaryTarget | GSK-3 |
PrimaryTargetIC<sub>50</sub> | 0.4and0.6nMforGSK-3αandGSK-3β,respectively |
Purity | ≥98%byHPLC |
PhysicochemicalInformation | |
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Cellpermeable | Y |
Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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Millipore常用产品报价单
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |