Description | |
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Overview | Acell-permeablemaleimidecompoundthatactsasapotent,reversIBLe,andATP-competitiveinhibitoragainstGSK-3β(Cat.No.361524)activity(IC50=34,67and304nMinthepresenceof10,30and100µMATP,respectively),whileexhibitingmuchreducedactivityagainstCdk2/A,KDR(71%and53%inhibition,respectively,at5µMinhibitorconcentration),andapanelof19otherkinases(IC50>5µM).ShowntopotentlyactivatecellularWntpathwayandincreaseβ-catenin-dependentreportertranscription(by15-foldat4µM)in293Tculturesinvitroand,whenappliedatorpriortotheshieldstageofembryo,interferewithzebrafishforebraindevelopmentinvivo. |
CatalogueNumber | 361564 |
BrandFamily | Calbiochem® |
Synonyms | 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione |
ProductInformation | |
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CASnumber | 159109-11-2 |
Form | Yellowsolid |
HillFormula | C₁₅H₁₄N₂O₄ |
Chemicalformula | C₁₅H₁₄N₂O₄ |
StructureformulaImage |
StorageandShippingInformation | |
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ShipCode | AmbientTemperatureOnly |
Toxicity | StandardHandling |
Storage | -20°C |
ProtectfromLight | Protectfromlight |
Donotfreeze | Oktofreeze |
SpecialInstructions | Followingreconstitution,aliquotandfreeze(-20°C).Stocksolutionsarestableforupto6monthsat-20°C. |
Applications |
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BIOLOGicalInformation | |
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Purity | ≥95%byHPLC |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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Millipore常用产品报价单
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |