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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Millipore/361571 | InSolution™ GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem/361571/
产品编号:361571
市  场 价:¥4520.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$226.00
品      牌: Millipore
公      司:Millipore
公司分类:
Millipore/361571 | InSolution™ GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 - Calbiochem/361571/
商品介绍
Description
OverviewAcell-permeableaminopyrimidinecompoundthatactsaspotent,ATP-competitive,andhighlyselectiveGSK-3inhibitor(IC50=10and6.7nMagainstGSK-3αandGSK-3β,respectively).Exhibitslittleornoactivitytoward46otherenzymes(IC50>8.8µMagainst20kinasesandKi≥5µMagainst23non-kinaseenzymes)andshowsonlyweakbindingto22pharmacologicallyrelevantreceptors(Kd~4µM).Thiscompoundisorallyavailableandisshowntoeffectivelyimproveglucosemetabolisminbothmurineandrattype2diabetesmodelsinvivo.Thesolidformofthiscompound(Cat.No.361559)isalsoavailable.
CatalogueNumber361571
BrandFamilyCalbiochem®
Synonyms6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile
ProductInformation
CASnumber252917-06-9
FormLiquid
FormulationA25mM(5mg/430µL)solutionofGSK-3InhibitorXVI,CHIR99021(Cat.No.361559)inDMSO.
HillFormulaC₂₂H₁₈Cl₂N₈
HygroscopicHygroscopic
ReversIBLeY
StructureformulaImage
StorageandShippingInformation
ShipCodeDryIceOnly
ToxicityIrritant
Storage≤-70°C
ProtectfromLightProtectfromlight
HygroscopicHygroscopic
Avoidfreeze/thawAvoidfreeze/thaw
DonotfreezeOktofreeze
SpecialInstructionsFollowinginitialthaw,aliquotandfreeze(-70°C).Aliquotsarestableforupto6monthsat-70°C.
Applications
BIOLOGicalInformation
PrimaryTargetGSK-3αandβ
PrimaryTargetIC<sub>50</sub>10and6.7nMagainstGSK-3&alpha
Purity≥95%byHPLC
PhysicochemicalInformation
CellpermeableY
Dimensions
MaterialsInformation
MaterialsInformation
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