Description | |
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Overview | Acell-permeableaminopyrimidinecompoundthatactsaspotent,ATP-competitive,andhighlyselectiveGSK-3inhibitor(IC50=10and6.7nMagainstGSK-3αandGSK-3β,respectively).Exhibitslittleornoactivitytoward46otherenzymes(IC50>8.8µMagainst20kinasesandKi≥5µMagainst23non-kinaseenzymes)andshowsonlyweakbindingto22pharmacologicallyrelevantreceptors(Kd~4µM).Thiscompoundisorallyavailableandisshowntoeffectivelyimproveglucosemetabolisminbothmurineandrattype2diabetesmodelsinvivo.Thesolidformofthiscompound(Cat.No.361559)isalsoavailable. |
CatalogueNumber | 361571 |
BrandFamily | Calbiochem® |
Synonyms | 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile |
ProductInformation | |
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CASnumber | 252917-06-9 |
Form | Liquid |
Formulation | A25mM(5mg/430µL)solutionofGSK-3InhibitorXVI,CHIR99021(Cat.No.361559)inDMSO. |
HillFormula | C₂₂H₁₈Cl₂N₈ |
Hygroscopic | Hygroscopic |
ReversIBLe | Y |
StructureformulaImage |
StorageandShippingInformation | |
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ShipCode | DryIceOnly |
Toxicity | Irritant |
Storage | ≤-70°C |
ProtectfromLight | Protectfromlight |
Hygroscopic | Hygroscopic |
Avoidfreeze/thaw | Avoidfreeze/thaw |
Donotfreeze | Oktofreeze |
SpecialInstructions | Followinginitialthaw,aliquotandfreeze(-70°C).Aliquotsarestableforupto6monthsat-70°C. |
Applications |
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BIOLOGicalInformation | |
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PrimaryTarget | GSK-3αandβ |
PrimaryTargetIC<sub>50</sub> | 10and6.7nMagainstGSK-3&alpha |
Purity | ≥95%byHPLC |
PhysicochemicalInformation | |
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Cellpermeable | Y |
Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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Millipore常用产品报价单
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Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |