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主营：分子类，蛋白类，抗体类，生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Millipore/FCCS025210 | FlowCellect™ PI3K-mTOR Signaling Cascade kit /FCCS025210/25 Tests / Kit
产品编号：FCCS025210
市  场 价：¥0.00
场      地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
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美  元  价：待定
品      牌： Millipore
公      司：Millipore
公司分类：
Millipore/FCCS025210 | FlowCellect™ PI3K-mTOR Signaling Cascade kit /FCCS025210/25 Tests / Kit
商品介绍
Description
CatalogueNumberFCCS025210
TradeName
  • FlowCellect
DescriptionFlowCellect™PI3K-mTORSignalingCascadekit
OverviewSignalingthroughthePI3K/Akt/mTORpathwayisconstitutivelyactiveinmanycancercellsduetothelossofPTEN(tumorsuppressor),exposuretocarcinogens,activationofgrowthreceptors,aswellasmutationsoramplificationsofPI3KorAkt.Therelevanceofthispathwayindifficulttotreatcancersmakesthesessignalingnodesprimetargetsinadvancinganticancertherapies.

Millipore’sFlowCellect™PI3K-mTORAnalysisKitincludestwodirectlyconjugatedphospho-specificsignalingantibodieswhichareoptimizedformulti-colorflowcytometryapplicationstoanalyzethemTORpathwayingreatdetail.ThephosphorylationofAktisindicativeoftheupstreamPI3Ksignaling,markingthecellsinitiationintoproliferationorcellsurvival.Phosporylated-RibosomalS6proteinisindicativeofdownstreammTORandp70S6KsignalingleADIngtoproteintranslation.

Byprovidingbothoftheseantibodiesinonekit,theresearcherhasthecompletesolutionwhenexaminingthemTORpathwaywhichisbeneficialfortheelucidationofdrugeffectivenessintheircancerresearch.
AlternateNames
  • FlowCellect
BackgroundInformationExaminationofcellsignalingpathwaysandmonitoringtheiractivationstatushavebeenextremelyimportantforresearcherstounderstandthedetailedmechanismsofcellularfunctionsandthecauseofvariousdiseases.Manysignaltransductionpathwayshavebeenimplicatedtoleadtomultipleoutcomessuchasapoptosis,celldifferentiation,cellgrowthandcellproliferation,allofwhichhavebeenextensivelystudiedforthetreatmentofvariouscancersandautoimmunediseases.

Thestudyofcellsignalingpathwaysarenowmadeeasierwiththeuseofactivationstatus-specificandphospho-specificantibodies.Measurementofproteinphosphorylationwithphospho-specificantibodieshasgiveninsightintokinasesignalingcascades[Krutzik,P.O.etal.(2003].Multi-parameterphosphoflowcytometryisapowerfultoolforstudyingmultiplepathwaysinamixedcellpopulationatthesametime.

Milliporeoffersarangeofnovelantibodybasedmulti-parameterFlowCellect™kitswhicharespecificallydesignedtoaddressthecurrentneedsinphosphoflowcytometryanalysisofcellsignalingpathwaysandcancerresearchinamulti-parametricfashion.Alloftheantibodiesprovidedinthekithavebeendirectlyconjugatedandoptimizedformulti-colorflowcytometryapplications.Byusingacombinationofantibodiesprovidedinthekit,researcherscannowaccuratelymeasurekeysignalingnodesandendpointsactivations.Moreover,researcherscanalsodissectanyparticularlinearsignalingpathwaycascadebymeasuringtheactivationofseveralcomponentsinatimecoursedependentmanner.ByusingtheFlowCellect™PI3K-mTORSignalingCascadekit,theresearchercannowstudymTORingreaterdetailanditsrelationshipingeneralcellfunctionsuchascellproliferation,apoptosisandcancer.

AllFlowCellect™kitsareoptimizedonthebench-topGuava®flowcytometrysystems,whichsavesvaluabletimeandsamplevolume.Allkitscontainoptimizedfixation,permeABIlization,washandflowbufferstoprovideresearcherswithacompletesolutionforsimultaneousdetectionofmultiplepathwayactivations.WiththeGuavaplatformandFlowCellect™kits,onecanfinallyhaveaneasy,reliableandfullyvalidatedsolutiontostudythecomplexcellsignalingpathwaysrightinthecomfortofyourownlab.
ProductInformation
Components
  • 1.20XAnti-phospho-RibosomalProteinS6(Ser235)PerCPconjugateMonoclonalAntibody:(PartNo.CS203308)One150µLvial
  • 2.20XAnti-phospho-Akt1/PKBα(Ser473)AlexaFluor488conjugateMonoclonalAntibody:(PartNo.CS203310)One150µLvial
  • 3.FixationBuffer:(PartNo.CS202122)One13mLbottle
  • 4.10XWashBuffer:(PartNo.CS202123)One13mLbottle
  • 5.5XAssayBuffer:(PartNo.CS202124)One55mLbottle
  • 6.1XPermeabilizationBuffer:(PartNo.CS203284)Two13mLbottles
Detectionmethod125IFluorescent
StorageandShippingInformation
StorageConditions4-8°Cforantibodiesandbuffers
Applications
ApplicationThisFlowCellectPI3K-mTORAnalysisKitincludestwodirectlyconjugatedphospho-specificsignalingantibodieswhichareoptimizedformulti-colorflowcytometryapplicationstoanalyzethemTORpathwayingreatdetail.
KeyApplications
  • FlowCytometry
BIOLOGicalInformation
HostRabbit/Murine
SpeciesReactivity
  • Human
AntibodyTypeMonoclonalAntibody
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍

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