商品介绍
| Description | |
|---|---|
| CatalogueNumber | CBL431 |
| Replaces | CBL437 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-N-MycAntibody,cloneIA8 |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Themonoclonalispresentedataconcentrationof100μg/1mlinphosphatebufferedsalinecontaining10mMsodiumazideand1mg/mlbovineserumalbumin.Werecommendthateachlaboratorydetermineanoptimumworkingtitreforuseinitsparticularapplication. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Forusewithin1monthofpurchasestoreat+4°C,forlongtermstoragealiquotantibodyintosmallvolumesandstoreat-20C. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | HumanN-mycsequence334-343+Cys. |
| Clone | IA8 |
| Host | Mouse |
| Specificity | Theantibodyreactswithamajorpeptide-blockablebandat62-64kDaonwesternblots. |
| Isotype | IgG2b |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneisamemberoftheMYCfamilyandencodesaproteinwithabasichelix-loop-helix(bHLH)domain.ThisproteinislocatedinthenucleusandmustdimerizewithanotherbHLHproteininordertobindDNA.Amplificationofthisgeneisassociatedwithavarietyoftumors,mostnotablyneuroblastomas.[providedbyRefSeq]. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:Mayfunctionasatranscriptionfactor. SIZE:464aminoacids;49561Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasanheterodimerwithMAX.InteractswithKDM5A,KDM5BandHUWE1. SUBCELLULARLOCATION:Nucleus. DEVELOPMENTALSTAGE:Expressedduringfetaldevelopment. DISEASE:AmplificationoftheN-MYCgeneisassociatedwithavarietyofhumantumors,mostfrequentlyneuroblastoma,wherethelevelofamplificationappearstoincreaseasthetumorprogresses. DefectsinMYCNarethecauseofFeingoldsyndrome;alsoknownasoculodigitoesophagoduodenalsyndrome(ODED).Feingoldsyndromeischaracterizedbyvariablecombinationsofesophagealandduodenalatresias,microcephaly,learningdisABIlityandlimbmalformations.Cardiacandrenalmalformations,vertebralanomalies,anddeafnesshavealsobeendescribed. DefectsinMYCNarethecauseofmicrocephalyanddigitalabnormalitieswithnormalintelligence. SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
Millipore常用产品报价单
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |
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