商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1431 |
| Replaces | AB3126 |
| Description | Anti-Tie-2Antibody,NT |
| AlternateNames |
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| BackgroundInformation | Tie-2isamemberofthetyrosineproteinkinasefamily,isatransmembranereceptorforangiopoietin1,andmayrepresentoneoftheearliestMarkersforcelllineagewithinmammalianendothelialcells.Itsexpressionisalmostonlyfoundinhuman,mouseandratendothelialcellsandangioblasts.Mostlikely,Tie-2regulatesthedifferentiation,properdispersal,andproliferationofthesecellsduringangiogenesis.MutationsinTEKareacauseofVMCMordominantlyinheritedvenousmalformationswhicharecharacterizedbyserpiginious,dilatedveins.Tie-2canbefoundinplacentaandlungtissue.Lowerlevelsoftheproteincanalsobefoundinkidney,umbilicalveinendothelialcells,andbrain. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Affinitypurifiedimmunoglobulin.Liquidin100mMTris,pH7.5,containing0.2%BSAand0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | ThisAnti-Tie-2Antibody,N-terminusisvalidatedforuseinWBforthedetectionofTie-2. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | 18aminoacidpeptidesequencewithintheextracellular,N-terminusofhumanTie-2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizeshumanTunicainternalendothelialcellkinase(TIE-2),alsodescribedasAngiopoietin-1receptor,p140TEK,ortyrosineproteinkinasereceptor.Thepeptidesequenceusedasimmunogenis100%conservedinhuman,rat,mouse,and94%inbovine. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. SUBUNITSTRUCTURE:InteractswithPTPRB. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. PTM:Phosphorylated.PhosphorylationisinducedbyANGPT1andANGPT2.ANGPT1-inducedphosphorylationisimpairedduringhypoxia.DephosphorylatedbyPTPRB. INVOLVEMENTINDISEASE:DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily. Contains3EGF-likedomains. Contains3fibronectintype-IIIdomains. Contains2Ig-likeC2-type(immunoglobulin-like)domains. Contains1proteinkinasedomain. |
| MolecularWeight | Approx.126kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
Millipore常用产品报价单
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |
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