商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABT44 |
| Description | Anti-ICAM-3(CD50)Antibody,cloneCBR-IC3/1 |
| AlternateNames |
|
| BackgroundInformation | Intercellularadhesionmolecule3(ICAM-3orCD50)isaleukocytedifferentiationantigen.ICAM-3isthoughttobeimportantintheadhesionofthefirststagesoftheimmuneresponse.ICAM-3mayalsoplayaroleinactivatingTlymphocytes.ICAM-3isfoundinhighlevelsonrestinglymphocytesandisanimportantligandforLFA-1.ICAM-3istyrosinephosphorylatedandisassociatedwithtyrosinekinaseactivityinhumanneutrophils.ICAM-3maybethereceptorglycoproteinthatistheinitialbacterialbindingsiteforinfectiveendocarditisbyoralstreptococci. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SKW3cells |
| Clone | CBR-IC31 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberoftheintercellularadhesionmolecule(ICAM)family.AllICAMproteinsaretypeItransmembraneglycoproteins,contain2-9immunoglobulin-likeC2-typedomains,andbindtotheleukocyteadhesionLFA-1protein.ThisproteinisconstitutivelyandabundantlyexpressedbyallleucocytesandmaybethemostimportantligandforLFA-1intheinitiationoftheimmuneresponse.Itfunctionsnotonlyasanadhesionmolecule,butalsoasapotentsignallingmolecule.[providedbyRefSeq]. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:ICAMproteinsareligandsfortheleukocyteadhesionproteinLFA-1(integrinalpha-L/beta-2).ICAM3isalsoaligandforintegrinalpha-D/beta-2. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. PTM:Uponstimulationbyaphysiologicstimulibecomesrapidlyandtransientlyphosphorylatedonserineresidues. N-glycosylated;glycansconsistofamixtureoftri-andtetra-antennarycomplex-typechainsandhigh-mannosechains. SEQUENCESIMILARITIES:Belongstotheimmunoglobulinsuperfamily.ICAMfamily. Contains5Ig-likeC2-type(immunoglobulin-like)domains. |
| MolecularWeight | 59kDacalculated |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
Millipore常用产品报价单
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |
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