商品介绍
| Description | |
|---|---|
| CatalogueNumber | 14-597 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | HistoneH2A.ZProtein,humanrecombinant,100µg |
| Overview | RecombinanthumanhistoneH2A.Z |
| ProductInformation |
|---|
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat4°C |
| Applications | |
|---|---|
| Application | RecombinanthumanhistoneH2A.Z,producedinE.coli,purifiedbyionexchangechromotography.ForuseinKinaseAssays. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Source | producedinE.coli |
| SpecificActivity | ForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme. |
| EntrezGeneNumber | |
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.Thisgeneencodesareplication-independentmemberofthehistoneH2Afamilythatisdistinctfromothermembersofthefamily.StudiesinmicehaveshownthatthisparticularhistoneisrequiredforembryonicdevelopmentandindicatethatlackoffunctionalhistoneH2Aleadstoembryoniclethality. |
| GeneSymbol |
|
| PurificationMethod | Ion-exchangechromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P0C0S5#VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Maybeinvolvedintheformationofconstitutiveheterochromatin.Mayberequiredforchromosomesegregationduringcelldivision. SIZE:128aminoacids;13553Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.H2AoritsvariantH2AFZformsanheterodimerwithH2B.H2AFZinteractswithINCENP(Bysimilarity). SUBCELLULARLOCATION:Nucleus. PTM:MonoubiquitinationofLys-122givesaspecifictagforepigenetictranscriptionalrepression.&AcetylatedonLys-5,Lys-8andLys-12duringinterphase.Acetylationdisappearsatmitosis(Bysimilarity).&Notphosphorylated(Bysimilarity). SIMILARITY:SwissProt:P0C0S5##BelongstothehistoneH2Afamily. |
| MolecularWeight | 16kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
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| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| Millipore/475855-1R神奇滤布 密理博Millipore现货促销 | 475855-1R | Life Science Research | 膜 | 93.50 | Millipore/17-701/EZ-Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit | 17-701 | Life Science Research | 定量试剂盒 | 653.00 | Millipore/RIPAb+ Ago2 - RIP Validated Antibody and Primer Set | 03-110 | Life Science Research | 抗体套装 | 433.00 | Millipore/CBL468F | Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated/CBL468F/100 assays | CBL468F | Antibodies and Assays | 功能性抗体 | 298.00 | Millipore/ECM460 | αVβ3/PECAM Investigator Kit/ECM460/1 kit | ECM460 | Antibodies and Assays | 夹心法ELISA | 477.00 |
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